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Patricia S Doyle Selected Research

cruzipain

1/2013Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.
9/2011The Trypanosoma cruzi protease cruzain mediates immune evasion.
9/2010In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
2/2010Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.
5/2008Identification of a new class of nonpeptidic inhibitors of cruzain.
11/2007A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.

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Patricia S Doyle Research Topics

Disease

10Chagas Disease (American Trypanosomiasis)
01/2013 - 11/2007
2Infections
09/2011 - 11/2007
2Parasitic Diseases (Parasitic Disease)
09/2010 - 10/2008
2Neglected Diseases
08/2010 - 02/2010
2Leishmaniasis
10/2008 - 01/2008
1Mycoses (Diseases, Fungus)
06/2010
1Toxoplasmosis
01/2008
1Malaria
01/2008
1Giardiasis
01/2008
1Amebiasis (Amoebiasis)
01/2008

Drug/Important Bio-Agent (IBA)

6cruzipainIBA
01/2013 - 11/2007
5Cysteine Proteases (Cysteine Protease)IBA
01/2013 - 05/2008
5Pharmaceutical PreparationsIBA
08/2010 - 11/2007
2Peptide Hydrolases (Proteases)FDA Link
09/2011 - 11/2007
2EnzymesIBA
09/2010 - 01/2009
2SterolsIBA
06/2010 - 01/2009
1Biological ProductsIBA
09/2011
1N- methylpiperazine- urea- arginyl- homophenylalanyl- vinylsulfonebenzeneIBA
09/2010
114-alpha Demethylase InhibitorsIBA
06/2010
1posaconazoleFDA Link
06/2010
1ER 30346 (ravuconazole)IBA
06/2010
1AzolesIBA
06/2010
1tetrafluorophenoxymethyl ketoneIBA
02/2010
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
01/2009
1Coordination ComplexesIBA
10/2008
1MetalsIBA
10/2008
1Cysteine Proteinase InhibitorsIBA
11/2007
1Recombinases (Recombinase)IBA
11/2007
1DipeptidesIBA
11/2007
1Protease Inhibitors (Protease Inhibitor)IBA
11/2007
1benzonidazole (benznidazole)IBA
11/2007
1NifurtimoxIBA
11/2007

Therapy/Procedure

4Drug Therapy (Chemotherapy)
02/2010 - 05/2008